Ligation of ICAM-2 and Interaction with LFA-1 Induces AKT Activity and Protects Primary B Cells from Apoptosis. ( A) Multiparameter FACS analysis illustrates ICAM-2-induced AKT activity in CD4+ and CD19+ populations protects from apoptosis. (B) PBMC were crosslinked for ICAM-1,-2,-3, CD43, or CD44(10ug/ml, 45 min) and subjected to phosphatidylinositol detection of phosphatidylinositol 3,4,5 triphosphate(PIP3)and phosphatidylinositol 4,5 bisphosphate(PIP2).

Perez OD, Kinoshita, S., Hitoshi, Y., Payan, DG, Kitamura, T., Nolan, GP and Lorens, JB. Activation of the PKB/AKT Pathway by ICAM-2 Immunity 2002 16:51-65.