Publications

Garry P. Nolan, Ph.D. and colleagues

G.P. Nolan. (1978). On the Foraging Strategies of Carnivorous Plants II. Carnivorous Plant Newsletter, Volume 7: 79-81.

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Okay, so this is an article I published when I was a teenager about these cool outer tentacles of Drosera burmanii that I showed were sensitive to a protein-motion mixture (and not motion alone). I postulated they were critical to push escaping insect victims back into the center of the trap where they are to be digested.

There is a lot to learn from something like this regarding students methinks....

Nolan GP.
2008. Featured Scientist Interview by ScienceWatch.com. Tracking Trends and Performance in Basic Research. April 2008. Interview Link
Hale MB, Krutzik PO, Samra SS, Crane JM, Nolan GP.. (2009) Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus. PLoS One. 2009 Aug 25;4(8):e6756. PUBMED Abstract
Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD Jr, van Rooijen N, Weissman IL. (2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009 Jul 23;138(2):286-99. PUBMED Abstract
O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas AK. (2009). The initial phase of an immune response functions to activate regulatory T cells. J Immunol. 2009 Jul 1;183(1):332-9. PUBMED Abstract
Hotson AN, Hardy JW, Hale MB, Contag CH, Nolan GP. (2009). The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol. 2009 Jun 15;182(12):7558-68. PUBMED Abstract
Shachaf CM, Elchuri SV, Koh AL, Zhu J, Nguyen LN, Mitchell DJ, Zhang J, Swartz KB, Sun L, Chan S, Sinclair R, Nolan GP (2009). A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs). PLoS ONE. 2009;4(4):e5206. Epub 2009 Apr 15. PUBMED Abstract
Sachs K, Itani S, Carlisle J, Nolan GP, Pe'er D, Lauffenburger DA (2009). Learning signaling network structures with sparsely distributed data. J Comput Biol. 2009 Feb;16(2):201-12. PUBMED Abstract
Hammer MM, Kotecha N, Irish JM, Nolan GP, Krutzik PO. (2009). WebFlow: A Software Package for High-Throughput Analysis of Flow Cytometry Data.Assay Drug Dev Technol. 2009 Feb 2. PUBMED Abstract
Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML. (2008). Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008 Oct 7;14(4):335-43. PUBMED Abstract
Koh A, Shachaf C, Elchuri S, Nolan GP, Sinclair R.(2008) Electron Microscopy Characterization of Composite Organic-Inorganic Nanoparticles (COINs) as Raman Labels for Extra-cellular Analyses. Microsc Microanal. 2008 Aug;14 Suppl 2:670-1. PDF link
Shachaf CM, Gentles AJ, Elchuri S, Sahoo D, Soen Y, Sharpe O, Perez OD, Chang M, Mitchel D, Robinson WH, Dill D, Nolan GP, Plevritis SK, Felsher DW. (2008). Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res. 2008 Jul 1 68(13):5132-42. PUBMED Abstract
Lee AW, Sharp ER, O'Mahony A, Rosenberg MG, Israelski DM, Nolan GP, Nixon DF. (2008). Single cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo HIV-1 infection. J Virol. Apr;82(7):3702-12. Epub 2008 Jan 23. PUBMED Abstract
Krutzik PO, Crane JM, Clutter MR, and Nolan GP. (2008). High-content single-cell drug screening with phosphospecific flow cytometry. Nat Chem Biol. Feb;4(2):132-42. Epub 2007 Dec 23. PUBMED Abstract
Schulz K.R., Danna E.A., Krutzik P.O, and Nolan GP. (2007). Single-Cell Phospho-Protein Analysis by Flow Cytometry. Current Protocols in Immunology. Aug;8(17):1-20.
Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. (2007). K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. May 1;109(9):3945-52. Epub 2006 Dec 27. PUBMED Abstract
Nolan GP. (2007). What's wrong with drug screening today. Nat Chem Biol. Apr;3(4):187-91. PUBMED Abstract
Zampieri CA, Fortin JF, Nolan GP, and Nabel GJ. (2007). The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. J Virol. Feb;81(3):1230-40. Epub 2006 Nov 15. PUBMED Abstract
Irish JM, Anensen N, Hovland R, Skavland J, Borresen-Dale AL, Bruserud O, Nolan G.P. and Gjertsen BT. (2007). Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Blood. Mar 15;109(6):2589-96. Epub 2006 Nov 14. PUBMED Abstract
Krutzik P.O. and Nolan G.P. (2006). Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling, Nature Methods 3, 361-368. PUBMED Abstract
Irish JM, Czerwinski DK, Nolan G.P. and Levy R. (2006). Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol. Aug 1;177(3):1581-9. PUBMED Abstract
Irish JM, Czerwinski DK, Nolan G.P. and Levy R. (2006). Altered B cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor infiltrating non-malignant B cells. Blood. Jul 11; [Epub ahead of print]. PUBMED Abstract
Perez O.D. and Nolan G.P. (2006). Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level. Immunological Reviews. 210:208-28.
Irish J.M., Kotecha N. and Nolan G.P. (2006). Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nature Reviews Cancer. 6:146-55.
Danna E.A. and Nolan G.P. (2006). Transcending the biomarker mindset: deciphering disease mechanisms at the single cell level. Curr Opin Chem Biol. Feb;10(1):20-7. Epub 2006 Jan 6. PUBMED Abstract
Perez O.D. and Nolan G.P. (2005). Appreciating the heterogeneity in autoimmune disease: Multiparameter assessment of intracellular signaling mechanisms. New York Academy of Science, In press.
Krutzik P.O., Hale M.B. and Nolan G.P. (2005). Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J Immunol. Aug 15; 175(4): 2366-73. PUBMED Abstract
Krutzik P.O., Clutter M.R. and Nolan G.P. (2005). Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J Immunol. Aug 15; 175(4): 2357-65. PUBMED Abstract
Perez O.D, Mitchell D., Gao G., Li L., Campos R. and Nolan G.P. (2005). Multiparameter analysis of intracellular phosphoepitopes in immunophenotyped cell populations by flow cytometry. Current Protocols in Cytometry.
Aug;6(20):1-22.
Sachs K., Perez O., Pe'er D., Lauffenburger D.A and Nolan G.P. 2005. Causal protein-signaling networks derived from multiparameter single-cell data. Science. Apr 22;308 (5721):523-9. PUBMED Abstract
Nolan G.P. (2005). Tadpoles by the Tail. Nat Methods. Jan;2(1):11-2. No abstract.
Berquin I.M., Pang B., Dziubinski M.L., Scott L.M., Chen Y.Q., Nolan G.P. and Ethier S.P. (2005). Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene. Feb21; [Epub ahead of print]. PUBMED Abstract
Stitz J., Krutzik P.O. and Nolan G.P. (2005). Screening of retroviral cDNA libraries for factors involved in protein phosphorylation in signaling cascades. Nucleic Acids Res. Feb 24;33(4):e39. PUBMED Abstract
Wolkowicz R. and Nolan G.P. (2005). Gene therapy progress and prospects: novel gene therapy approaches for AIDS. Gene Ther. Mar; 12(6): 467-76. PUBMED Abstract
Wolkowicz R., Jager G. and Nolan G.P. (2005). A Random peptide library fused to CCR5 for selection of mimetopes expressed on the mammalian cell surface via retroviral vectors. J Biol Chem. Jan 18 [epub ahead of print]. PUBMED Abstract
Perez O.D, Mitchell D., Gao G., Li L., Campos R. and Nolan G.P. (2004). Flow Cytometric phosphoepitope profiling of cell populations. Purdue Press.
Irish J.M., Hovland R., Krutzik P.O., Perez O.D., Bruserud O., Gjertsen B.T., Nolan G.P. (2004) Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells. Cell. Jul 23;118(2):217-228. PUBMED Abstract
Condiotti R., Curran M.A., Nolan G.P., Giladi H., Ketzinel-Gilad M., Gross E. and Galun E. (2004) Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem Biophys Res Commun. 2004 Jul 30;320(3):998-1006. PUBMED Abstract
Marks K.M., Braun P.D. and Nolan G.P. (2004) A general approach for chemical labeling and rapid, spatially controlled protein inactivation. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):9982-7. Epub 2004 Jun 24. PUBMED Abstract
Perez O.D., MitchelL D., Jager G.C., Nolan G.P. (2004) LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells. Blood. Apr 27. PUBMED Abstract
Marks K.M., Rosinov M., and Nolan G.P. (2004) In Vivo Targeting of Organic Calcium Sensors via Genetically Selected Peptides. Chemistry and Biology. March, Vol 11, 347-356. PUBMED Abstract
Krutzik P.O., Irish J., Nolan G.P., and Perez O.D. (2004) Analysis of Phospho-Proteins by Flow Cytometry: Techniques and Clinical Applications. Clin Immunol. Mar;110(3):206-21. PUBMED Abstract
Perez O.D., Krutzik P.O, and Nolan G.P. (2004) Flow Cytometric Analysis of Kinase Signaling Cascades. Methods Mol Biol. 263:67-94. PUBMED Abstract
Wolkowicz R., Nolan G.P. and Curran M.A. (2004) Lentiviral vectors for the delivery of DNA into mammalian cells. Methods Mol Biol. 246:391-411. PUBMED Abstract
Hale M.B., Nolan G.P. and Wolkowicz R. (2004) Oligonucleotide-directed site-specific integration of high complexity libraries into ssDNA templates. Nucleic Acids Res. Jan 29;32(2):E22. PUBMED Abstract
Perez, O.D. and Nolan G.P. (2004)Advancements in single-cell phospho -proteomics. Cellular Dynamics Newsletter, BD Biosciences.
Perez O.D., Mitchell D., Jager G.C., South S., Murriel C., McBride J., Herzenberg L.A., Kinoshita S., Nolan G.P. (2003). Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol. Nov;4(11):1083-92. Epub 2003 Oct 05. PUBMED Abstract
Krutzik P.O. and Nolan G.P. (2003). Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry Oct;55A(2):61-70. PUBMED Abstract
Tarner I.H., Slavin A.J., McBride J., Levicnik A., Smith R., Nolan G.P., Contag C.H., Fathman C.G. (2003). Treatment of autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad Sci. Sep;998:512-9. PUBMED Abstract
Smith R., Tarner I.H., Hollenhorst M., Lin C., Levicnik A.U., Fathman C.G., Nolan G.P. (2003). Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. Gene Ther. Aug;10(15):1248-57. PUBMED Abstract
Pashine A., Busch R., Belmares M.P., Munning J.N., Doebele R.C., Buckingham M., Nolan G.P., Mellins E.D. (2003). Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides. Immunity. Aug;19(2):183-92. PUBMED Abstract
Scappaticci F.A., Contreras A., Boswell C.A., Lewis J.S. and Nolan G.P. (2003). Polyclonal antibodies to xenogeneic endothelial cells induce apoptosis and block support of tumor growth in mice. Vaccine 21: 2667-2677. PUBMED Abstract
Scappaticci F.A. and Nolan G.P. (2003). Introduction of Anti-tumor Immunity in Mice Using a Syngeneic Endothelial Cell Vaccine. Anticancer Res. 2003 Mar-Apr; 23(2B): 1165-72. PUBMED Abstract
Wolkowicz R., Nolan G.P. (2003) Retroviral Technology - Applications for Expressed Peptide Libraries. Front Biosci. May 1;8:D603-D619. PUBMED Abstract
Price M.A., Case S.S., Carbonaro D.A., Yu X.J., Petersen D., Sabo K.M., Curran M.A., Engel B.C., Margarian H., Abkowitz J.L., Nolan G.P. , Kohn D.B., Crooks G.M. (2002) Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Mol Ther. Nov;6(5):645-52. PUBMED Abstract
Perez O.D., Nolan G.P., Magda D., Miller R.A., Herzenberg L.A., and Herzenberg L.A. (2002) Motexafin gadolinium selectively induces apoptosis in HIV-1 infected CD4+ T helper cells. Proc Natl Acad Sci U S A. Feb 19;99(4):2270-4. PUBMED Abstract
Perez O.D. and Nolan G.P. (2002) Simultaneous measurement of multiple kinase activation states by polychromatic flow cytometry. Nat Biotechnol. Feb;20(2):155-162. PUBMED Abstract.
Fletcher B.S., Dragstedt C., Notterpek L., Nolan G.P. (2002) Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. Leukemia. Aug;16(8):1507-18. PUBMED Abstract
Fortin J.F., Nolan G.P. (2002) Recognizing a something when your library sees it. Chem Biol. Jun;9(6):670-2. PUBMED Abstract
Curran M.A. and Nolan G.P. (2002) Recombinant feline immunodeficiency virus vectors. Preparation and use. Methods Mol Med. 69:335-50.
Scappaticci F.A., Contreras A., Smith R., Bonhoure L., Lum B., Cao Y., Engleman E.G. and Nolan G.P. (2002). Statin-AE: A novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity. Angiogenesis. 4(4):263-8. PUBMED Abstract
Curran M.A. and Nolan G.P. (2002) Nonprimate Lentiviral Vectors. Curr Top Microbiol Immunol. 261:75-105.
Perez O.D., Kinoshita S., Hitoshi Y., Payan D.G., Kitamura T., Lorens J.B. and Nolan G.P. (2002). Activation of PKB/AKT-Dependent Cell Survival by Intracellular Adhesion Molecule-2 (ICAM-2). Immunity. Jan;16(1):51-65. PUBMED Abstract
Perez O.D. and Nolan G.P. (2001) Resistance is Futile: HIV-1 virion assimilation of host cell processes. Immunity vol. 15, 687-690. PUBMED Abstract
Nolan G.P. (2001). Genetic selection and the lure of SIN. Nat Biotechnol. 19(9):824-5.
Berquin I.M., Dziubinski M.L., Nolan G.P., and Ethier S.P. (2001). A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene. Jul 5;20(30):4019-28. PUBMED Abstract
Scappaticci F.A., Smith R., Pathak A., Schloss D., Lum B., Cai Y., Johnson F., Engleman E.G., and Nolan G.P. (2001) Combination Angiostantin and Endostatin gene transfer induces synergistic antiangiogenic activity and antitomor efficacy in leukema and solid tumors in mice. Mol Ther. 3: 186-96. PUBMED Abstract
Orentas R.J., Roskopf S.J., Nolan G.P. and Nishimura M.I. (2001) Retroviral Transduction of a T Cell Receptor Specific for an Epstein-Barr Virus-Encoded Peptide. Clin Immunol. 98:220-228. PUBMED Abstract
Xu X., leo C., Jang Y., Chan E., Padilla D., Huang B.C., Lin T., Gururaja T., Hitoshi Y., Lorens J.B., Anderson D.C., Sikic B., Luo Y., Payan D.G., Xu X. and Nolan G.P. (2001) Dominant effector genetics in mammalian cells. Nat Genet. 27:23-9. PUBMED Abstract
Staal F.J., Meeldijk J., Moerer P., Jay P., van de Weerdt B.C., Vainio S., Nolan G.P. and Clevers H. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol. 31:285-93. PUBMED Abstract
Smith R. and Nolan G.P. (2000) Retroviral and lentiviral gene therapy for autoimmune disease. Curr Dir Autoimmun. 2:167-88.
Michiels F., van der Kammen R.A., Janssen L., Nolan G. and Collard J.G. (2000) Expression of Rho GTPases using retroviral vectors. Methods Enzymol. 325:295-302
Thorsen V.A., Bjorndal B., Nolan G., Fukami M.H., Bruland O., Lillehaug J.R. and Holmsen H. (2000) Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis. Biochim Biophys Acta. 1487:163-76. PUBMED Abstract
Rabizadeh S., Ye X., Sperandio S., Wang J.J., Ellerby H.M., Ellerby L.M., Giza C., Andrusiak R.L., Frankowski H., Yaron Y., Moayeri N.N., Rovelli G., Evans C.J., Butcher L.L., Nolan G.P., Assa-Munt N. and Bredesen D.E. (2000) Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor. J Mol Neurosci. 15:215-29. PUBMED Abstract
Lorens JB, Bennett MK, Pearsall DM, Throndset WR, Rossi AB, Armstrong RJ, Fox BP, Chan EH, Luo Y, Masuda E, Ferrick DA, Anderson DC, Payan DG, Nolan GP. Retroviral delivery of peptide modulators of cellular functions. Mol Ther. 2000 1:438-47. PUBMED Abstract
Costa, G.L., Benson, J.M., Seroogy, C.M., Achacoso, P., Fathman, C.G., and Nolan, G.P. (2000) Targeting Rare Populations of Murine Antigen-Specific T Lymphocytes by Retroviral Transduction for Potential Application in Gene Therapy for Autoimmune Disease. J. Immunology. 164(7):3581-3590. PUBMED Abstract
Curran, M.A., Kaiser, S.M., Achacoso, P.L., and Nolan, G.P. (2000) Efficient Transduction of Non-Dividing Cells by Optimized Feline Immunodeficiency Virus Vectors. Molecular Therapy. Pp. 31-38. PUBMED Abstract

Please Note: The complete Nolan Lab publication list can be found at the Nolan Lab website publication page.

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